Xi'an Yuanyu Biological Co., Ltd.
Synonyms---Lingzhi Mushroom ,Ganoderma lucidum Mushroom, Mannentake
Chemical Name: Beta-Glucan, Beta-D-Glucan, Beta-(1,3)-D-Glucan
Molecular Formula: C18H30O14X2
Mol. Wt.: 470.42
Chemical Name: Triterpenes, Triterpene saponins, Ganoderic acid A( a compound isolated from the Reishi mushroom)
Cas No.: 81907-62-2
Molecular Formula: C30H44O7
Mol. Wt.: 516.67
Reishi mushroom is the name for one form of the mushroom Ganoderma lucidum, and its close relative Ganoderma tsugae. Ganoderma lucidum enjoys special veneration in Asia, where it has been used as a medicinal mushroom in traditional Chinese medicine for more than 4,000 years, making it one of the oldest mushrooms known to have been used in medicine.
The word lingzhi, in Chinese, means "herb of spiritual potency" and has also been described as "mushroom of immortality". Because of its presumed health benefits and apparent absence of side-effects, it has attained a reputation in the East as the ultimate herbal substance. Lingzhi is listed in the American Herbal Pharmacopoeia and Therapeutic Compendium.
Ganoderma lucidum produces a group of triterpenes, called ganoderic acids, which have a molecular structure similar to steroid hormones. It also contains other compounds many of which are typically found in fungal materials, such as Maitake, Shitake, Agaricus blazei, Agaricus biporus, including polysaccharides such as beta-glucan, coumarin, mannitol, and alkaloids.
Ganoderic acids are a class of closely related triterpenes found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia. Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the best characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection, anti-tumor effects, and 5-alpha reductase inhibition.
The Reishi Mushroom Extract used in dietary supplements is derived from the whole mushroom (the fruiting bodies of Ganodema fungi). The red Reishi Mushroom is better than the black Reishi Mushroom, and the former taste more bitter than the latter.
Reishi Mushroom contains a high concentration of beta-glucan and Granoderic acids (Triterpenes), compounds which has been shown to stimulate immune system and anti-tumor:
• Up-regulate the immune system (Immunomodulatory and immunotherapeutic activities)
• Anti-cancer, anti-tumor, and anti-neoplastic effects
•Prevent cancer metastasis
•Anti-bacterial and anti-viral activities
• Beneficial effect on Lowering Blood Pressure(via inhibition of angiotensin-converting enzyme)
• Beneficial effect on Lowering Blood Sugar
• Beneficial effect on Lowering Cholesterol
• Protective effects against liver injury by viruses and other toxic agents
• Weight loss aid
Beta-glucan and the immune system
Beta-glucans are known as "biological response modifiers" because of their ability to activate the immune system. Immunologists at the University of Louisville, discovered that a receptor on the surface of innate immune cells called Complement Receptor 3 (CR3 or CD11b/CD18) is responsible for binding to beta-glucans, allowing the immune cells to recognize them as "non-self." However, it should be noted that the activity of beta-glucans is different from some pharmaceutical drugs which have the ability to over-stimulate the immune system. Pharmaceutical drugs have the potential to push the immune system to over-stimulation, and hence are contraindicated in individuals with autoimmune diseases, allergies, or yeast infections. Beta-glucans seem to make the immune system work better without becoming overactive. In addition to enhancing the activity of the immune system, beta-glucans also reportedly lower elevated levels of LDL cholesterol, aid in wound healing, help prevent infections, and have potential as an adjuvant in the treatment of cancer.
Lingzhi may possess anti-tumor, immunomodulatory and immunotherapeutic activities, supported by studies on polysaccharides, terpenes, and other bioactive compounds isolated from fruiting bodies and mycelia of this fungus. It has also been found to inhibit platelet aggregation, and to lower blood pressure (via inhibition of angiotensin-converting enzyme), cholesterol and blood sugar.
Besides effects on mammalian physiology, Ganoderma is reported to have anti-bacterial and anti-viral activities. Ganoderma is reported to exhibit direct anti-viral with the following viruses; HSV-1, HSV-2, influenza virus, vesicular stomatitis. Ganoderma mushrooms are reported to exhibit direct anti-microbial properties with the following organisms; aspergillus niger, bacillus cereus, candida albicans, and escherichia coli.
Some oriental preparations containing Lingzhi extract are marketed as a weight loss aid. They are advertised as a "slimming formula" in Japanese markets and Lingzi is combined with other herbal extracts. Research is scarce to show the validity of these claims in terms of Lingzhi as a weight loss aid.
Reishi Mushroom Extract is safe. No side and harmful effect have been found.
• The typical dose is 500-1500mg per day (usually in 2-3 doses throughout the day).
• Consult physicians for different condition specifics.
GNI’s Reishi Mushroom Extract Features and Benefits:
Reishi Mushroom Extract is one of GNI's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Ganodema lucidum Mushroom
• Produced with pure water only
• High purity: over 30%(Polysaccharides as Beta-glucan and 4% Treiterpenes
• NO solvent - residual free
• Crystal yellow-Brown in appearance
• High solubility in water
• High anti-bacteria, and longer shelf life
Ganoderma lucidum extract (also known as Ganoderma lucidum powder) is timely harvest mature mature fruiting bodies, dried by hot water extraction (or alcohol extraction), vacuum concentration, spray drying process, obtained Ganoderma extract powder, is Ganoderma lucidum powder concentrated from high-power Ganoderma lucidum essence.
Ganoderma lucidum powder due to the use of raw materials and extraction process, the quality is very different. From the raw materials, with the spores of basswood lychee fruiting bodies as the raw material extracted from the best quality powder, collected over the quality of basswood linden red Ganoderma lucidum followed by the quality of Ganoderma lucidum powder extracted bag material quality Poor; from the extraction process, the cost of extraction with alcohol than the water to mention the high quality is also better. Production of 1 kg of good Ganoderma lucidum powder requires about 25 kg Ganoderma lucidum dry goods per gram of Ganoderma lucidum powder equivalent to the medicinal value of 25 grams of logs Ganoderma lucidum. Therefore, the Ganoderma lucidum powder is one of the high-tech products in Ganoderma lucidum, with higher medicinal value, as the raw materials developed by most of the products are high-end products. However, some manufacturers in order to make their products have a price advantage, they take some very low-level method, in the extraction of Ganoderma lucidum powder, the first mixed with dextrin or starch in the raw materials, which is dextrin or starch as Ganoderma powder to buy. Ganoderma powder buyers must not seek the sake of small profits, and forget the quality of products, in the attitude of being responsible for the consumer, do not forget the "cheap not good goods, good goods is not cheap" truth.
Ganoderma lucidum extract and Ganoderma lucidum powder are two concepts: (Individuals do not agree with the above view, with refined powder for the concept of extract)
Ganoderma lucidum extract is selected Ganoderma lucidum, the solid-state fermentation, extraction of which the active ingredient
Ganoderma lucidum powder is crushed after drying,
And there is a qualitative difference is one of the nutrients contained in the extract and the powder also has a great amount of difference, the extraction of one ton of Ganoderma lucidum extract
The yield of the extract is between 4 and 6%, and there is no loss of the refined powder.
Ganoderma lucidum contains chemical composition is very complex, including the following categories:
1. Polysaccharides: Ganoderma lucidum polysaccharide and its monosaccharide composition has been determined more than 60 kinds.
2. Amino acids: Ganoderma lucidum and Ganoderma lucidum in the amino acid types similar, but their content is different from the amino acids are aspartic acid, glutamic acid, arginine, lysine, ornithine, proline, Alanine, glycine, serine, threonine, tyrosine, valine, leucine, phenylalanine, isoleucine, hydroxyproline, histidine, methionine and so on, There are sulfur-containing amino acids in the powder.
3. Trace elements: organic germanium as the main active ingredient. Organic germanium content of ginseng 4 to 6 times, as a powerful immune enhancer.
4. Alkaloids: Ganoderma alkaloids in the low content of our spores from Ganoderma lucidum and Ganoderma lucidum are divided into the alkaloid choline (choline), betaine (betaine), and its hydrochloride, Ganoderma lucidum Ganoine, ganodine and niacin.
english name:(22E)-Ergosta-5,7,22-trien-3beta-ol; Provitamin D2; ergosta-5,7,22-trien-3-ol; (3beta,22E)-ergosta-5,7,22-trien-3-ol; (22E)-ergosta-5,7,22-trien-3-ol; (3S,9S,10R,13R,17R)-10,13-dimethyl-17-[(E)-1,4,5-trimethylhex-2-enyl]-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
Type:reishi mushroom extract
Packaging:Drum, Plastic Container, Vacuum Packed
Place of Origin:Shaanxi, China (Mainland)
Grade:Pharm & Food Grade
Model Number:100% Nature
Product Name:Reishi mushroom extract
Solution:100% In Water
Drying Method::Spray drying
Particle Size (80 mesh)::100% pass 80mesh
Total Heavy Metals::<2 ppm
Total Plate Count:<1000/g
Ganoderma lucidum extraction of many ways, we use ethanol extraction, ether - water distribution, and then ethyl acetate - water distribution. The ether portion, the ethyl acetate portion and the water portion were obtained. Ethyl ether part of the acid-base treatment were neutral fat-soluble and acidic fat-soluble part. From the neutral portion of the fatty acids and sterol compounds; from the acidic fat soluble part of the triterpenoid compounds; from the ethyl acetate part of the alkaloid and furan derivatives derived from the water-soluble part of the nucleoside and amino acids ingredient.
Separation of the liposoluble fraction of Ganoderma lucidum was mostly by repeated silica gel column chromatography, the pure part of the preparation of thin, low pressure column chromatography, high performance liquid chromatography (positive and negative phase) preparation methods such as separation and purification. Separation of water-soluble components Isolation and purification using ion-exchange resins and macroporous resins. Silica gel chromatography commonly used solvent system for chloroform - methanol, petroleum ether - ethyl acetate, ethyl acetate - acetone.
Thin layer identification method Ganoderma lucidum extract dissolved in ethanol, over 732 [H +] resin column, washed with water and ammonium hydroxide, the eluate was concentrated under vacuum, extracted with petroleum ether, and then extracted with chloroform. The chloroform extract was eluted with methanol and the methanol extract was precipitated by silicotungstic acid. The precipitate was dissolved in 50% acetone, treated with 732 resin and precipitated twice with ethanol. The washed portion was collected by concentration on an activated carbon column Paper chromatography, using ethanol - ammonia (28%) (4: 1) after the start of bismuth potassium iodide color. The Rf of? -trimethylaminobutyric acid is 0.69.
1. How long have your company run on active pharmaceutical ingredients?
12 years focusing on pharma field,8 years exporting experience.
2. Which payment terms are you accept?
Payment term: L/C D/A D/P T/T Western Union MoneyGram
3. After an order is placed, when to deliver?
It depends on whether the products you buy has inventory. If we have inventory, generally we can arrange
shipment after receipt of payment 2 to 3 days. If not, it will be decided by the time of the factory production.
4. How about your company's certification?
GMP, FDA, EP, BP etc.