Xi'an Yuanyu Biological Co., Ltd.
|Payment Type:||L/C,T/T,D/P,Money Gram,Western Union|
|Terms of Trade:||FOB,CIF,FCA|
|Min. Order:||1 Kilogram|
|Delivery Time:||7 Days|
What is Mulberry Leaf Extract( Folium Mori Extract )?
Overwhelming scientific evidence from research conducted at top medical institutions in the United States, India, France, and throughout Asia, prove that the Mulberry Leaf is one of the most powerful natural herbal supplements, and it can no longer be ignored as a potent solution to many health issues.
One of the most comprehensive studies was a 5-year research project that conclusively determined Mulberry Leaves to have various preventive effects on adult diseases, weight management and improves overall wellness.
One of the most amazing characteristic that can only be found in the Mulberry Leaf is an ingredient known as moranoline(1-Deoxynojirimycin/ 1-DNJ) which inhibits an enzyme in the intestinal tract (alpha-glycosidase) involved in the digestion of carbohydrates. Moranolineor 1-DNJ holds back complex carbohydrates, starches, maltose and sucrose from breaking down into glucose. In essence, it actually prevents sugar from entering into the bloodstream. It does this by inhibiting the oxidation of LDL-cholesterol which is a major factor in the development of atherosclerotic plaque. This health benefit( Herbal for Diabetic ) proves to be most significant in treating diabetes, which has quickly become one of the leading diseases in the world.
What is 1-Deoxy nojirimycin(DNJ)?
1-Deoxynojirimycin(1-DNJ), hereinafter referred to as DNJ, is a powerful α-glucosidase inhibitors( Mulberry Leaf Extract Diabetes ).After being absorbed by human body,it could inhibit the activity of invertase,maltose enzyme, α-glucosidase and α-amylase enzyme, reduce absorption of carbohydrate digestion and glucose, reduce blood sugar,and its hypoglycemic activity is better than sulfonylureas,and its side effects,such as hypoglycemia, is much more less than other hypoglycemic drugs, it also has a good safety; besides, this product has little influence on the normal eating. In addition, DNJ also has significant antiretroviral activity, it could inhibit tumor metastasis and be used as a carrier for the synthesis of high pure maltose.
1-Deoxynojirimycin(DNJ) is one of alkaloid present in Mulberry leaves and root bark. DNJ is naturally occurs in other plants and microbes,such as Commelina communis, Hyacinthus orientalis and Streptomyces Lavendulae GC-148. We extracte the DNJ both from leaf and bark of Morus alba L.
Specifications of1-Deoxy nojirimycin(DNJ)
|Discription:||Brown or yellow Mulberry Extract Powder|
|Purity and Specification:||1%, 1.5%, 2%,10%,20%,30% HPLC|
Function & Characteristics of 1-Deoxy nojirimycin(DNJ)
a. High hypoglycemic effect.
b.. Antiviral activity.
c. helpful to improve skin metabolism and purify skin
d.Mulberry Leaf Extract Weight Loss
a. Select from 100% natural Mulberry with a special process.
c.Low ash,impurity,heavy metal,solvent residue and no pesticide residue.
d. Complete product tracing systerm and technical service.
Specification Sheet of 1-Deoxy nojirimycin(DNJ)
|APPEARANCE||BROWN POWDER/ Mulberry Leaf Powder Extraction|
|COUNTRY OF ORIGIN||CHINA|
|PARTICLE SIZE||THROUGH 80 MESH|
|PLANT PART USED||LEAF|
|ASSAY(HPLC)||1%, 1.5%, 2%, 10%, 20% ,30%|
|EXTRACT SOLVENTS||ETHANOL & WATER|
|LOSS ON DRYING||≤5.0%|
|PESTICIDE RESIDUE (GC)|
|666||≤ 0.1 ppm|
|DDT||≤ 0.1 ppm|
|ACEPHATE||≤ 0.02 ppm|
|METHAMIDOPHOS||≤ 0.5 ppm|
|TOTAL PLATE COUNT||≤1000CFU/G|
|YEASTS AND MOLDS||≤100 CFU/G|
Package:25kg/drum,double layers plastic bags inside.
Safety:DNJ is a natural plant extract with little side-effect.Our Services
We guarantee a 100% natural & high quality with 8 years production experience & technical research.We owned a over 2,000,000 square meters planting base, which ensures our production capacity, also the product quality.Company Information
Hunan Geneham Biomedical Technology Ltd., founded in 2006, is located in Changsha, Hunan, mainly produces and sells plant extracts and raw materials of health care food, researches and develops pharmaceutical and health care products.We own a rosemary plantation base with an area of nearly2,000,000 square meterin Hunan, which is available to provide pure natural organic rosemary raw materials.
The major rosemary products involve in carnosic acid, rosmarinic acid, ursolic acid, 4-hyroxy isoleucine, fenugreek saponin, high-purity tea saponin, and 1-DNJ,which all have remarkable advantages in price and quality. The factory has passed the certifications of HACCP, ISO9001 and ISO20002, has production lines and biomechanical research institutions of plant extract and health care food raw materials, guaranteeing the quality safety of products.
Company Strong Products
Pharm. Standard Workshop
Morus alba leaves, spades shaped, are the preferred feedstock for silkworms, and are also cut for food for livestock (cattle, goats, etc.) in areas where dry seasons restrict the availability of ground vegetation. The leaves were also long used for medicinal purposes.
In traditional Chinese medicine, the leaves are considered to be of sweet, bitter and cold properties, which are associated with the liver and lung meridians, and functions to clear lung heat (to manifest as a fever, headache,
sore throat or cough) and clear fire in the liver. They are also used to stop bleeding, especially in patients who
are vomiting blood.
In vitro studies have also shown that decoctions made from fresh mulberry leaves can inhibit the progress of
several bacteria, including S. aureus and hemolytics streptococcus. The nearest research shows that mulberry leaves extract with its active compounds glycoprotein (1-Deoxynojirimcin (DNJ)) and polysaccharides, which are a strong Inhibitor of glucosidase I (Ki = 2.1 mM) and II (Ki = 7 mM), can also play a role in the management and treatment of diabetes, and for the same metabolism mechanism, it can also help to control obesity very effectively.
The morus alba leaf extract helps restore the vascular reactivity of diabetic rats. Free radical-induced vascular dysfunction plays a key role in the pathogenesis of vascular disease found in chronic diabetic patients. An ethanolic extract of mulberry leaf had antihyperglycemic, antioxidant and antiglycation effects in chronic diabetic rats, which may suggest its use as food supplement for diabetics. Morus alba plant leaf extract has been studied to process potent antisnake venom property, especially against the local and systemic effects of Daboia russelii venom.
Mulberry Leaf components: leaves containing rutin, quercetin, isoquercitrin, quercetin-3-trioside glucoside, traces of β-sitosterol, and campesterol sterols, β-sitosterol, β-D- Glycosides, hopolinol, meso-inositol, insect metamorphic bovine asteroids and ecdysterone, hemolysin, chlorogenic acid Deoxynojirimycin.
Deoxynojirimycin(DNJ) is a kind of alkaloid present in Mulberry leaves and root bark. DNJ is naturally occurs in in other plants and microbes.
Botanical resource: mulberry leaf, Morus alba L.
Latin Name: Folium Mori, Ramulus Mori
Part of Plant Used: Leaf
Active Ingredients: 1-Deoxynojirimycin (1-DNJ)
Specifications: 1%~20% 1-DNJ
Testing Method: HPLC
CAS No.: 19130-96-2
Molecular Formula: C6H13NO4
Molecular Weight: 163.17
Appearance: Brown Powder
Type:Fruit Extract, Fruit Extract
Variety:mulberry leaf extract, Mulberry leaf
Extraction Type:Solvent Extraction
Packaging:Bottle, Can, Drum, Glass Container, Mason Jar, Plastic Container, Vacuum Packed
Place of Origin:Shaanxi, China (Mainland)
Product name:mulberry leaf extract
Particle size:98%through 80 mesh
1, the optimal extraction process of mulberry polysaccharide is as follows: the purified water is solvent, the ratio of material to liquid is 1:15, 90 ℃
Reflux extraction twice, each 100rain. The combined extracts were concentrated and precipitated with 50% ethanol to obtain total polysaccharides
MPl, the yield was 11.84%.
2. DEAE-cellulose column and Sephadex G. 100 column chromatography to further purify MPl
MPll, MPl2, MPl3. By means of chromatography and chemical analysis,
The monosaccharide composition MPl1 consists mainly of rhamnose, arabinose, xylose, mannose, glucose and semi-
Lactose, and its molar ratio was 21: 16: 3: 3: 1: 20; MPl2 was mainly composed of rhamnose and glucose,
The molar ratio of 3: 1: MPl3 mainly composed of rhamnose.
The optimum extraction process of total flavonoids from mulberry leaves was as follows: 70% ethanol, 20 times of crude drug, 85 ℃ extraction
Twice, each time 2h. The total flavonoids of mulberry leaves with purity of 37% were obtained with the yield of 28.1%.
The adsorption capacity of total flavonoids in mulberry leaves was investigated. Four kinds of macroporous adsorption resins were screened, and s-8
Type resin adsorption and desorption properties of the best, the total flavonoids adsorption of mulberry leaf 31.62mg / g wet resin, desorption
The rate was 82.69%. And the dynamic adsorption performance of the resin was studied. The saturated adsorption capacity of the resin was 29.8 mg / g wet
Resin, the best desorption process for 30% ethanol 11 column volumes (Bv) elution and 50% ethanol 5 column volumes
(BV). The purity of total flavonoids was 76.63% and the extraction rate was 72%. S-8 resin regeneration performance is good.
5, on the s. 8 macroporous adsorption resin and purified total flavonoids of mulberry leaves after the organic solvent residue into
Line of research. The results showed that the pretreated S. 8 resin is almost free of organic solvent residue;
Leaf total flavonoids also did not detect organic solvent residues. Which indicates that the pretreatment method is effective and feasible
The treated resin can be used for purification of total flavonoids from mulberry leaves.
1. How does Mulberry Leaf Extract 1-Deoxynojirimycin diabetes products works?
1-Deoxynojirimycin(DNJ) is a kind of alkaloid present in Mulberry leaves and root bark.DNJ is approved to have effects on lowering blood glucose, Antiviral activity and help to improve skin metabolism and purify skin.
Research shows that when DNJ entered the body, it can inhibit the decomposition of starch and sugar by sucrase, maltase, α-glucosidase, α-amylase enzyme, thus blocking the body's absorption of sugar, and inhibit the increase of glucose without diet change. In addition, DNJ can inhibit the glucose modification process of HIV membrane glycoprotein. Meanwhile, the accumulation of immature glycoproteins may inhibit the cell fusion and the binding between virus and host cell receptor, and the formation of cell body harmony to inhibit the the replication of MoLV so as to inhibit the viral activity.
2. What's the function of Mulberry Leaf Extract 1-Deoxynojirimycin diabetes products ?
Mulberry Leaf is considered as a nice herb in the ancient China for anti-inflammation, anti-aging and maintaining health. Mulberry leaf is rich in amino acids,vitamin C and antioxidants. Among this components, the most valuable are Rutoside and DNJ(1-Deoxynojimycin),The latest Chinese research has shown Rutoside and DNJ are effective in regulating blood fat, balancing blood pressure, reducing blood glucose, and boosting metabolism. So they are widely used as raw materials for curing diabetes.
3. What’s the effect of Mulberry Leaf Extract 1-Deoxynojirimycin diabetes products on Blood Lipid Profiles in Humans?
Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.